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Ancient literature of Ayurveda suggests that the colloidal preparation of swarna (gold particles) with honey and ghee would significantly induce robust immunity similar to the vaccines. Various studies have already shown that, Gold particles are the most promising ones which do not affect living cells and do not produce adverse effects. Suvarnaprashana comprises of administration of colloidal formulation of gold wherein the gold particles are of various different size, shape, charge and bio-molecular compositions. Owing to the molecular ingredients found in ghee and honey, these particles retain high stability, low toxicity and and immunogenicity. The molecular ingredients also contain sugars, amino acids, proteins, lipids, vitamins and other components. All these components help in capping the gold particles in Suvarnaprashana medicine which therefore '''exhibits multivalent interactions between the particle and membrane receptor of antigen-presenting cells (APCs) such as dendritic cells.''' Dendritic cells are antigen-presenting cells (also known as accessory cells) of the human immune system. These cells are responsible for initiating all antigen-specific immune responses. These cells are especially sensitive to signals derived from microbes, allergens, and the airway tissue microenvironment. Moreover these cells also effectively link the innate and adaptive arms of the immune system. Therefore '''targeting these dendritic cells is considered to be one of the efficient strategies in promoting immunotherapies and vaccine development. Thus, Suvanraprashana modulates the immunity by acting on cells like dendritic cells.'''  

Ancient literature of Ayurveda suggests that the colloidal preparation of swarna (gold particles) with honey and ghee would significantly induce robust immunity similar to the vaccines. Various studies have already shown that, Gold particles are the most promising ones which do not affect living cells and do not produce adverse effects. Suvarnaprashana comprises of administration of colloidal formulation of gold wherein the gold particles are of various different size, shape, charge and bio-molecular compositions. Owing to the molecular ingredients found in ghee and honey, these particles retain high stability, low toxicity and and immunogenicity. The molecular ingredients also contain sugars, amino acids, proteins, lipids, vitamins and other components. All these components help in capping the gold particles in Suvarnaprashana medicine which therefore '''exhibits multivalent interactions between the particle and membrane receptor of antigen-presenting cells (APCs) such as dendritic cells.''' Dendritic cells are antigen-presenting cells (also known as accessory cells) of the human immune system. These cells are responsible for initiating all antigen-specific immune responses. These cells are especially sensitive to signals derived from microbes, allergens, and the airway tissue microenvironment. Moreover these cells also effectively link the innate and adaptive arms of the immune system. Therefore '''targeting these dendritic cells is considered to be one of the efficient strategies in promoting immunotherapies and vaccine development. Thus, Suvanraprashana modulates the immunity by acting on cells like dendritic cells.'''  

'''The plausible mechanism by which Suvarna prashana affects dendritic cells function is as follows,'''

The plausible mechanism by which Suvarna prashana affects dendritic cells function is as follows,

Immature dendritic cells uptake and internalize particles of Suvarnaprashana in their cytosol by various methods.  

* Immature dendritic cells uptake and internalize particles of Suvarnaprashana in their cytosol by various methods.  

 

* Then the immature cells differentiate into mature dendritic cells evident by morphological changes in dendritic cells as well as expression of immune markers like CD 83 & CD 86.  

Then the immature cells differentiate into mature dendritic cells evident by morphological changes in dendritic cells as well as expression of immune markers like CD 83 & CD 86.  

* since the gold particles in this SP formulation comprise of mosaic features in terms of size, shape, charge, and composition, after internalization they cause intercellular trafficking in dendritic cells Therefore, dendritic cells present multiple antigens effectively to the T cells. This can lead to development of Non-specific immunity in a child which can protect the child from multiple infectious diseases and improve tolerance as well. 

 

since the gold particles in this SP formulation comprise of mosaic features in terms of size, shape, charge, and composition, after internalization they cause intercellular trafficking in dendritic cells Therefore, dendritic cells present multiple antigens effectively to the T cells.  

The potential application of swarna prashana in immunomodulation is the development of both prophylactic and therapeutic vaccine.

The potential application of swarna prashana in immunomodulation is the development of both prophylactic and therapeutic vaccine.

== Hypothesis ==

== Hypothesis ==

Suvarnaprashana boosts immune system, protein metabolism and optimum secretion of growth hormone in children of growing age.  

Suvarnaprashana boosts immunity, protein metabolism and optimum secretion of growth hormone in children of growing age.  

== References ==

== References ==

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[[Category:Ayurveda]]

[[Category:Ayurveda]]