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The term 'Asthi' in samskrit refers to a 'Bone'. Thus Asthi dhatu mentioned in Ayurveda is similar to bony tissue in human body. In a literal sense, the word Asthi means that entity which doesn't get destroyed easily and stays longer as compared to all other counterparts. It is well known that even after years of burial is human bodies, the remnant tissue which one can find is bone. Thus bone or asthi is that component which is not easily destroyed naturally. In human beings Asthi dhatu performs the vital function of forming the skeleton, providing stability and shape.   
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The term 'Asthi' in samskrit refers to a 'Bone'. Thus Asthi dhatu mentioned in Ayurveda is similar to bony tissue in human body. In a literal sense, the word Asthi means that entity which doesn't get destroyed easily and stays longer as compared to all other counterparts. It is well known that even after years of burial of human bodies, the remnant tissue which one can find is bone. Thus bone or asthi is that body component which is not easily destroyed naturally very rapidly. In human beings Asthi dhatu performs the vital function of forming the skeleton, providing stability and shape.   
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=== Etymology and derivation ===
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=== Characteristic feature of Asthi dhatu ===
The word Asthi is a combination of two Sanskrit words "as” and “kthin”. They together give the meaning “stability”. It denotes a bone or the kernel of a fruit.
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Asthi dhatu is identified by Ayurveda acharyas by its peculiar feature of strength. Acharya sushruta has beautifully explained the properties, role and importance of Asthi dhatu with example as follows,
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=== Definition ===
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अभ्यन्तरगतैः सारैर्यथा तिष्ठन्ति भूरुहाः | अस्थिसारैस्तथा देहा ध्रियन्ते देहिनां ध्रुवम् ||२१||
Asthi is a body component which stays for a longer time (asyate) and which takes part in movements (kshipyate) with muscles. It is also termed as the extract (sara) of the body which remains even after the destruction of all other body components. [Su.Sa.Sharira Sthana 5/21-22]
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== Fundamental constitution (panchabhautika sanghatana) and properties ==
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तस्माच्चिरविनष्टेषु त्वङ्मांसेषु शरीरिणाम् | अस्थीनि न विनश्यन्ति साराण्येतानि देहिनाम् |
Fundamental constitution of asthi dhatu shows predominance of Prithvi mahabhuta.
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* The physical properties of "asthi dhatu" are heaviness (guru), roughness (khara), hardness (kathina), bulkiness (sthula), static (sthira), with a definite physical form (murtimanta).
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मांसान्यत्र निबद्धानि सिराभिः स्नायुभिस्तथा | अस्थीन्यालम्बनं कृत्वा न शीर्यन्ते पतन्ति वा ||२३||
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Meaning: Physical bodies of the humans are held stable by the strong asthi like the trees are held strong rooted to the ground due to their strong stem (heartwood). Since asthi are like the essence of the body those never decay and get destroyed long after decaying of mansa and twak (Muscular tissue and skin). Various sira (vessels, nerves) and snayu (tendons, ligaments) are attached to asthi and those are held in place because of asthi which themselves never decay or fall.
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Thus Asthi dhatu is also termed as the extract (sara) of the body (Su.sha 5/21-22]
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== Panchabhautika constitution  ==
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Asthi dhatu is that tissue which is called as essence or extract of body. It is strong, hard and stable. Therefore it is clear that it has Prithvi mahabhuta dominance in it. At the same time it is also khara (dry and rough) in texture. (Cha chi 15/24,25) This property of Asthi is developed during its generation from meda dhatu by the action of Teja and Vayu along with Pruthvi. Also Asthi is one of the chief sites of vata residence. Thus Along with Pruthvi, Asthi dhatu has dominant vayu and teja mahabhuta as well.
 
== Metabolism and Development ==
 
== Metabolism and Development ==
 
The asthi dhatu is formed from its predecessor adipose tissue (meda dhatu). The nourishing portion of adipose tissue (meda dhatu) and constituents of nutrient fluid (ahara rasa) are transformed into asthi dhatu by action of factors responsible for its metabolism (asthi dhatvagni). Agni mahabhuta and vayu mahabhuta play a major role in the solidification and roughness of asthi by acting upon prithvi mahabhuta components of adipose tissue (meda dhatu).[Cha. Sa. Chikitsa Sthana 15/30]
 
The asthi dhatu is formed from its predecessor adipose tissue (meda dhatu). The nourishing portion of adipose tissue (meda dhatu) and constituents of nutrient fluid (ahara rasa) are transformed into asthi dhatu by action of factors responsible for its metabolism (asthi dhatvagni). Agni mahabhuta and vayu mahabhuta play a major role in the solidification and roughness of asthi by acting upon prithvi mahabhuta components of adipose tissue (meda dhatu).[Cha. Sa. Chikitsa Sthana 15/30]
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Scalp hair (kesha) and body hair(loma) are waste products of metabolism of asthi dhatu. [Cha.Sa. Sutra Sthana 15/18]
 
Scalp hair (kesha) and body hair(loma) are waste products of metabolism of asthi dhatu. [Cha.Sa. Sutra Sthana 15/18]
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== Utpatti of Asthi dhatu ==
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The asthi dhatu is formed from its predecessor meda dhatu. When meda dhatu is subjected to the process of micro-transformation (सूक्ष्मपचनम्), one processed part of it is specifically utilized to provide nourishment to the next dhatu in order i.e. Asthi Dhatu (धातु). This part is responsible for development and nourishment of asthi dhatu in body. Transformation of this fluid and unctuous form of meda dhatu into solid and tough (cha chi 15 24, 30) form of asthi dhatu happens due to action of Pruthvi, Teja and Vayu mahabhutas and generation of excess dryness in the processed part. Excess dryness and hardness are thus the distinguishing features of asthi dhatu from all other dhatus.
    
== Characteristics of best quality or essence (asthisara) ==
 
== Characteristics of best quality or essence (asthisara) ==
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