| + | In swarna prashana, gold particles are encapsulated by honey, ghee, and herbs, and it helps the gold particles to form into various size, shape, charges, and composition. This irregular form of the gold particles in swarna prashana may induce the non-specific immunity by activating both cellular and humoral immunity [4, 9, 11, 12]. In general, pathogens undergo several mutations naturally or induced by man. Therefore, human system which acquired non-specific immunity will be ready to defend against any pathogens and inflammatory substances that enter or develop in our system [13]. It is evident that gold nanoparticles are efficiently interacting with the target cells in terms of immunological responses and cytotoxicity [14]. |
− | The gold use din Suvanraprashan is in purified and calcinated form known as Bhasma. Such processed form of gold has proven its safety since long time in may studies.<ref>Paul W, Sharma CP. Blood compatibility studies of Swarna bhasma (gold bhasma), an Ayurvedic drug. Int J Ayurveda Res. 2011 Jan;2(1):14-22. doi: 10.4103/0974-7788.83183. PMID: 21897638; PMCID: PMC3157103.</ref> <ref>Biswas S et al. Physicochemical characterization of Suvarna Bhasma, its toxicity profiling in rat and behavioural assessment in zebrafish model. Journal of Ethnopharmacology; Volume 249:2020,112388, ISSN 0378-8741. <nowiki>https://doi.org/10.1016/j.jep.2019.112388</nowiki>.</ref>Apart from that, in none of the clinical studies conducted on Suvarnaprashana, any adverse effects on the children have been reported.<ref name=":1" /> <ref name=":3" /> Therefore it can be stated that, Suvarnaprashana medicine prepared by an authentic, registered [[Vaidya (वैद्यः)|Vaidya]] or a pharmaceutical brand is safe for use. However it is best to take suvarnaprashana under a [[Vaidya (वैद्यः)|Vaidya's]] guidance. | + | The gold use din Suvanraprashan is in purified and calcinated form known as Bhasma. Such processed form of gold has proven its safety since long time in may studies.<ref>Paul W, Sharma CP. Blood compatibility studies of Swarna bhasma (gold bhasma), an Ayurvedic drug. Int J Ayurveda Res. 2011 Jan;2(1):14-22. doi: 10.4103/0974-7788.83183. PMID: 21897638; PMCID: PMC3157103.</ref> <ref>Biswas S et al. Physicochemical characterization of Suvarna Bhasma, its toxicity profiling in rat and behavioural assessment in zebrafish model. Journal of Ethnopharmacology; Volume 249:2020,112388, ISSN 0378-8741. <nowiki>https://doi.org/10.1016/j.jep.2019.112388</nowiki>.</ref>Apart from that, in none of the clinical studies conducted on Suvarnaprashana, any adverse effects on the children have been reported.<ref name=":1" /> <ref name=":3" /> Therefore it can be stated that, Suvarnaprashana medicine prepared by an authentic, registered [[Vaidya (वैद्यः)|Vaidya]] or a pharmaceutical brand is safe for use. However it is best to take suvarnaprashana under a [[Vaidya (वैद्यः)|Vaidya's]] guidance. |
| + | (TBE)Swarna prashana is related to the smaller gold particles perhaps containing wide variation in shapes, sizes, charges, and bio-molecular compositions [4]. These particles retain high stability, low toxicity, and immunogenicity conjugation due to the molecular ingredients found in ghee and honey [21]. The molecular ingredients contain sugars, amino acids, proteins, lipids, vitamins, and other components [10]. Moreover, these components help in capping the gold particles in swarna prashan which exhibits multivalent interactions between the particle and membrane receptor of antigen-presenting cells (APCs) such as dendritic cells [1, 4, 8]. Targeting these dendritic cells is considered to be one of the efficient strategies in promoting immunotherapies and vaccine development [8]. Therefore, the plausible mechanism of swarna prashana in interacting with dendritic cells is as follows: dendritic cells opt several mechanisms in the internalization of swarna prashana particles including receptor-mediated endocytosis, pinocytosis, and phagocytosis [1, 4, 5, 20]. Immature dendritic cells will uptake and internalize the swarna prashana particles in the cytosol. As a result, immature dendritic cells differentiate into mature dendritic that causes expression of CD83 and CD86 and also morphological changes in the maturation of the dendritic cells [8] (Fig. 1). The internalized particles, namely, antigens, are processed in the cytoplasm and initiate T cell response based on antigen presented through MHC complex [4, 7, 19]. Interestingly, swarna prashana particles comprise of mosaic features in terms of size, shape, charge, and composition of the particles which results in intercellular trafficking in dendritic cells [1, 4]. Therefore, dendritic cells present multiple antigens effectively to the T cells [20]. It is believed that the activated dendritic cells and T cells require soluble cytokines including IL-7, IL-6, IL-10, IL-12, IL-23, TNF, and IFN to exhibit immunogenic response [4, 8]. The potential application of swarna prashana in immunomodulation is the development of both prophylactic and therapeutic vaccine [4, 8, 19]. Ancient scripts have suggested that the colloidal preparation of swarna (gold particles) with honey and ghee would significantly induce robust immunity like vaccines [4, 8, 10]. Gold particles are the most promising ones which do not affect living cells and do not produce adverse effects [20]. It is believed that gold is used in ayurvedic, herbal, and herbo-mineral preparations for the treatment of chronic and degenerative disease without any side effect [12, 13, 17]. The advantages of biodegradable gold particles are utilization in the vaccinated organism, high loading efficiency for the target substance, enhanced ability to cross various physiological barriers, and low systemic side effects. In all likelihood, the immune actions of biodegradable nanoparticles and gold nanoparticles as corpuscular carriers are similar. The recent data indicating low toxicity of gold nanoparticles makes it being used in the development of next-generation vaccines [1, 8, 16]. However, no extensive studies on animals or cell lines model are available, and further clinical trials are required on interaction of swarna prashana particles and human functions. |