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== Mode of action ==
 
== Mode of action ==
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Raktamokshana plausible mechanism.
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<nowiki>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757849/</nowiki>
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(Indian journal of pharmaceutical sciences, Leech Therapeutic applications)
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(Dr. vasant c patil,principles and practice of panchakarma fifth edition, chaukhamba publications, chap 15th page no. 586,604)
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Systemic bloodletting is restricted to few conditions for e.g., Polycythaemia, hemochromatosis, but Raktamokshana has shown its miraculous effects in many diseases.
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Bloodletting in any form requires removal of blood at a superficial level, might be from capillaries or superficial distribution of veins. Raktamokshana removes the old, damaged blood cells and helps formation of new, this reduces the workload on liver and spleen.
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Removal of small quantities of blood, reduces volume of blood from body which directly impacts the pressure of blood over the blood vessels and heart.
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In conditions of necrosis, or graft implantations, leeches or raktamokshana is used to establish adequate blood supply locally.
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Many studies have found that leeches have various bioactive molecules in their secretions (e.g., Hirudin). These molecules have analgesic, anti-inflammatory, platelet inhibitory, anticoagulant functions and many others.
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Leech is a distinct example of an invertebrate, which possesses a highly developed mechanism by which they prevent blood clotting. There are many studies stating the anticancer effects of leech saliva extracts. Since coagulation is related to metastasis and tumour progression, blocking the cascade can have an antitumour effect.
    
== References ==
 
== References ==
 
<references />
 
<references />
 
[[Category:Ayurveda]]
 
[[Category:Ayurveda]]
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